中英JAMA尸检克雅氏

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A51-year-oldmanpresentedwithprogressivedifficultywalkingthatdevelopedover1monthshortlyafterheranamarathon.Hefrequentlyfellandhaddifficultyclimbingthestairs.Hestatedhehadhearingproblems,butwithfurtherquestioning,itwasdiscoveredheactuallyhaddifficultydecipheringspeech.Hedidnothavedizzinessonstandingnorbowelorbladderincontinence.Hedidnottakemedications,andhedranksocially.Hehadnofamilyhistoryofimbalanceproblems.Hestillworkedfull-timeasalawyer.

51岁男性患者1月前参加完马拉松比赛后出现进行行走困难,经常感觉到爬楼困难,并自觉有听力障碍,进一步询问病史可发现其有语言发音难以辨认的问题。病人无头晕,无大小便失禁。否认服药史,社交场合偶有饮酒。无平衡功能障碍家族史,职业是全职律师。

Hisneurologicalexaminationshowedmildcerebellarataxiawithoutmyoclonusorparkinsonism.HisMontrealCognitiveAssessmentscorewas28of30points(2pointsdeductedfrom“delayedrecall”).Puretoneaudiometryshowednoconductiveorsensorineuralhearingloss.Brainmagneticresonanceimaging(MRI)revealednoabnormalsignal,includingfromtheponsandcerebellum.A


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